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Noteworthy, TH downregulation has been observed in Parkinsons disease (PD) [74] and in early parkinsonism [75]
Elevated ROS levels could also provide the cause for early elevation of antiangiogenic or decrease in angiogenic factors at a time when the placenta needs more vascular development
SLC7A11 is thus one of the NRF 2 transcriptional targets mediating antioxidant responses
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