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The UPS is the primary intracellular non-lysosomal pathway for protein degradation, consisting of substrates, ubiquitin molecules, ubiquitin-activating enzymes (E1), ubiquitin-conjugating enzymes (E2), ubiquitin-ligase enzymes (E3), 26S proteasomes, and deubiquitinating enzymes (DUBs) 15,19,20,21

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Feng J, Chen K, Xia Y et al (2018) Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-B and TGF-1/Smad3 pathways
