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L., Martyn-St James, M., Rowse, G., & Weich, S

As a major risk factor for CVDs and cardiovascular complications, the relationship between plasma TMAO concentrations and the increased risks of CVDs in individuals with type 1 and 2 diabetes has been reported (137139)

Cell Rep 28(9):2275-87 e5 2019 PMC6857709 Seong D, Jeong M, Seo J, Lee JY, Hwang CH, Shin HC, Shin JY, Nam YW, Jo JY, Lee H, Kim HJ, Kim HR, Oh JH, Ha SJ, Kim SJ, Roe JS, Kim W, Cheong JW, Bae KH, Lee SC, Oberst A, Vandenabeele P, Shin DH, Lee EW, Song J

Summary ALA and ALC have demonstrated safe and significant improvement in neuropathic pain management in RCTs, with favorable side effect profiles primarily when used for DPN