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In the body, IGF-1Ec/MGF expression rises in muscle and other tissue after mechanical stress or damage, where it acts as an early repair-phase signal that helps start regeneration
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These conditions induce endothelial dysfunction and impair vasodilation, thereby reducing penile blood flow and compromising filling of the corpora cavernosa [15, 21,22,23,24]
doi: 10.1128/aem.01121-23 98 KrishnasamyS.AbellT
