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The peptide has a short half-life of approximately 15 minutes in vitro due to degradation by aminopeptidase-like enzymes, though research suggests it may be more stable in vivo due to binding interactions with carrier molecules in circulation

Although three RAMP types in humans form a complex with CTR TM and ECD domains in the structurally similar way [15], the sequence difference among RAMP types and additional N-glycosylation in RAMP3 may contribute to unique outcome in downstream signaling mediated by amylin receptor 3 activation

10.1055/s-0040-1712534 Semin Respir Crit Care Med

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