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Because the peptide survives gastric passage at approximately 80% structural integrity per the 2016 HPLC data but doesnt survive at 100% oral research protocols typically use higher doses than injectable equivalents to achieve comparable systemic exposure

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Cell Mol Immunol

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Specialized glands in the duodenal submucosa (Brnners glands) are able to sustain high levels of bicarbonate secretion to protect it from gastric acid and pepsin (557)

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