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Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease that has been classified by the World Health Organization (WHO) as one of the top five terminal diseases

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Discovered in 2015 by researcher Changhan David Lee and colleagues at the University of Southern California, MOTS-c sits at the intersection of some of the most active areas in longevity science: mitochondrial biology, insulin sensitivity, skeletal muscle metabolism, and the molecular response to exercise