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doi: 10.1021/acs.analchem.5b01556 176 XieGZhangSZhengXJiaW

Preclinical studies using murine models have demonstrated that administering chemotherapeutic agents like oxaliplatin 5-FU at specific circadian times can significantly enhance antitumor activity and reduce toxicity [70]

A study by Sangiovanni et al reported the effects of CBD and Cannabis Sativa Extract (CSE, standardized to 5% CBD) on human keratinocytes (HaCaT cells) and human dermal fibroblast (HDF) cells

During immunogenic cell death (ICD), intracellular damage-associated molecular patterns (DAMPs) such as ATP, endoplasmic reticulum calmodulin, and high mobility group protein B1 leaks to the extracellular space, which in turn activates DCs by interacting with its receptors and triggers anti-tumor immune responses in T lymphocytes (54)