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Furthermore, tolerogenic cells are more sensitive to mTOR and/or AMPK signaling inhibition

In a clinical study, 240 mg/day CoQ10 treatment for 6 months significantly improved liver steatosis in MASLD patients [172]

Other classical NRF2 target genes mRNA expression were also investigated by RT-PCR: Heme Oxygenase 1 (HO1) and NAD(P)H Quinone Dehydrogenase 1 (NQO1), and enzymes related to glutathione utilization, such as the Glutathione Peroxidases 1, 2 and 3 (GPx1, GPx2 and GPx3), with all of them having reduced expression in the NCI H23 compared to A549 cells (Supplementary Fig

Informed consent for use in research was obtained from donor families by the specialist nurse in organ donation in accordance with NHSBT guidelines, and this study was approved by the London-Surrey Borders National Research Ethics Service (reference 18/WA/0214) and the NHSBT ethics committee (reference 06/Q702/61)