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The researchers termed this "chronic cytoprotection." The cell-protection effect did not diminish with extended use

In cats, a small study looking at clinical enteropathy cases showed resolution of hypocobalaminemia in all cases with oral supplementation of 0.125-0.25mg once daily for 28-94d (Toresson et al, ECVIM 2015 poster abstract)

Most people notice increased energy, improved mood, and better fat metabolism within a few weeks
