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In a phase 2 study, comparing the results of the empagliflozin arm to the control arm showed a significant improvement in the electrophysiological studies and a significant decrease in the pain score and the mean serum levels of neuron-specific enolase and malondialdehyde in patients with DPN

One study showed that patients with FM who received frequent B12 injections with supplemental oral intake of B9 reported symptom relief, although the treatment was less effective in patients using opioids for pain management and more effective in patients taking thyroid hormones due to hypothyroidism [50]