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The aging process of fibroblasts during photoaging owing to UVB exposure is associated with ROS accumulation, which escalates proteasomes inhabitation and autophagy initiation (35)

Additionally, elevated homocysteine levels may indicate inefficient biosynthesis of essential proteins, caused by folate metabolism abnormalities

also, the diketone groups form chelates with heavy transition metals (Cu 2+ , Zn 2+ , and Fe 3+ ) that lessen their toxicity [41]
