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these genotype differences also seemed stronger in males

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Oxidative stress can result in vascular endothelial cell injury (83, 230234), neuronal cell compromise (66, 122, 123, 152, 156, 162, 233, 235245), alterations in neurotransmitters (69, 246, 247), myelin degradation (79, 224, 248252), cell senescence (55, 112, 253255), loss of stem cell proliferation (66, 168, 228, 241, 251, 256259), and cognitive impairment (120, 121, 200, 223, 243, 245, 260266)

Increased levels of free radicals, such as Reactive Oxygen Species (ROS) and hydrogen peroxide (H 2 O 2 ) are associated with cellular oxidative damage and disruption of cellular integrity (Agrawal and Jha, 2020)