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of the preamble of this proposed rule, we are proposing to modify the validation targeting ( criteria to include any hospital with a ERUB of the two-tailed confidence interval that is less than 75 percent and received an extraordinary circumstances exception (ECE) for one or more quarters beginning with the FY 2027 program year

The resulting cytokine cascade, often involving the Janus kinase (JAK)signal transducer and activator of transcription (STAT) pathway, recruits additional immune cells, sustaining perifollicular inflammation

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