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In the lungs, PQ causes widespread edema, acute alveolitis, alveolar collapse, inflammatory reactions in the vascular endothelium, pulmonary congestion, hemorrhage, and fibrosis in the long term (Dearden et al., 1978, 1982

A small amount of the drug is metabolized via the cytochrome P-450 pathway (to be specific, CYP3A4 and CYP2E1) into NAPQI, which is extremely toxic to liver tissue, as well as being a strong biochemical oxidizer

Pharmacokinetics and distribution of [35S]methylsulfonylmethane following oral administration to rats, 5

This premium IV contains: Folic Acid, L-Taurine, Alpha-Lipoic-Acid, and B12 No Fillers or Preservatives Every IV infusion is full potency, clean, and never diluted, ensuring maximum effectiveness and safety