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doi: 10.3389/fimmu.2025.1726210 Received 16 October 2025 Revised 02 November 2025 Accepted 22 December 2025 Published 13 January 2026 Volume 16 - 2025 Edited by Titto Augustine, Purdue University Indianapolis, United States Reviewed by Ran Tao, Texas A&M University Baylor College of Dentistry, United States Fangmin Zhong, Nanchang University, China Tengfei Liu, Shanghai Jiao Tong University, China Hailiang Wang, Qingdao University, China Fuwen Yao, Stanford University, United States Afrasim Moin, University of Hail, Saudi Arabia Xiao Wei, Chengdu University, China Updates Copyright 2026 Wu, Zhang, Jiang, Chen, Sun, Zha, Lin, Li, Pan, Chen, He, Chen and Chen