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e-f , ALT and AST liver damage serum markers (n = 6 for Control, n = 9 for GGsTop) (e) and percent change in body weight (n = 10 per group) (f) in mice treated bi-daily with vehicle (saline) or 5 mg/kg i.p
However, this study utilized only M1 macrophages under in vitro conditions, further in-depth in vivo and in vitro studies are required to validate these observations by using macrophage reprogramming approaches, such as small molecules drugs or gene editing techniques
