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Similar anti-GFP IPs from cell extracts transfected with an empty plasmid served as a control to identify non-specific binding proteins that were subsequently excluded
This means tirzepatide suppresses appetite through a mechanistic profile that partially overlaps with GLP-1 but adds unique GIP-mediated effects on fat metabolism and energy expenditure
(Source: PMC6073405 ) 2
High doses of amylin, however, may be able to overrun these receptors and reduce feeding by acting at other brain sites
