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Clinical studies have also found a 200-fold increased risk of HCC in people with iron overload, such as HH patients

Nat Protoc 1(6):31593165 Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA (2015) Glutathione activates virulence gene expression of an intracellular pathogen

Clinical series and recent reviews show high ID prevalence in cancers associated with chronic blood loss or systemic inflammation, where hepcidin-driven iron sequestration and impaired absorption commonly cause functional or absolute ID ( In clinical and in vivo contexts, ID in cancer patients can result from both systemic host factors and tumor-specific mechanisms

These inefficiencies add friction to what should be a fast, 5-minute visit