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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired

IGF-I assays: Current assay methodologies and their limitations

Additionally, a 2020 observational study published in the Journal of Dermatology and Dermatologic Surgery identified correlations between periorbital hyperpigmentation (dark circles under the eyes) and low serum ferritin levels an early indicator of iron deficiency