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58 Nonetheless, mechanisms for crossing the BBB with CDs remain poorly understood, and they are important areas of investigation for the development of future CDs or CD conjugates to penetrate the BBB for drug delivery

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Metal nanoparticles have garnered widespread interest in lung cancer research due to their facile synthesis, functionalization capabilities, high biocompatibility, and multifaceted theranostics profileHowever, they are not without drawbacks, such as low endosomal escape efficiency, hemolytic activity, high nephrotoxicity, and short circulation times [67, 68] (Table 1) (Fig