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Observations such as eosinophilic muscle fibers, disruption of intercalated discs, and severe mitochondrial degradation point to a progressive degenerative process that compromises cardiac tissue integrity

For instance, a diminished ability to passively diffuse across biological membranes can raise a significant challenge, particularly in the context of central nervous system (CNS) drug discovery, where the bloodbrain barrier (BBB) can be relatively impermeable to negatively charged carboxylate

doi: 10.1161/HYPERTENSIONAHA.115.05315 [DOI] [PMC free article] [PubMed] [Google Scholar] 117

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