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This seasonal pattern relates to several factors: Humidity changes: The transition from dry winter air to humid spring conditions Temperature fluctuations: Rapid weather changes stress the skin Allergen exposure: Spring pollens may trigger immune responses Sunlight variations: Changes in UV exposure affect skin biology Interestingly, while summer's heat and humidity might seem like they would worsen SD, the increased UV exposure actually has an anti-inflammatory effect that can improve symptoms

doi: 10.1111/j.1753-4887.2012.00493.x 28 PickardJMZengMYCarusoRNezG

[DOI] [PubMed] [Google Scholar] Staresinic M, Petrovic I, Novinscak T, et al

Storage: For optimal stability, store lyophilized vials at -20C and protect from direct light exposure until reconstitution