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Finally, in vivo and in vitro cNF models must originate from the same cell of origin as the human tumour, they must be driven to tumourigenesis by the same genetic drivers (intrinsic factors), undergo similar downstream transcription profiles, develop within a similar tumour microenvironment (extrinsic factors) and must be robust for preclinical screening

Adolescent Health, Medicine and Therapeutics

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And if you and others are seeing such great results in operative tissue, why isnt it being published in peer reviewed journals