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Last but not least, the real-life ICU scenario in which patients with ALI/ARDS were treated with a combination of pharmacological and non-pharmacological interventions is difficult to replicate in mouse models, and endpoint assessment in experimental models does not accurately reflect the disease progression in human ALI/ARDS [154]
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The device produces a biphasic emission, in which the propellant first launches droplets through the nasal valve and then deeper into the UNS, so deposition does not require breath coordination (Cooper et al., 2022)
Drug Approval Package (2006)
