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PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 - 2014)
33: 11723 Wieland OH, Deufel T, Paetzke-Brunner I
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In this regard, the metabolic conversion of alcohol into acetaldehyde has been recognized as critically involved [32, 33], and this suggestion was further extended by the observation that another molecule, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), obtainable by Pictet-Spengler condensation of acetaldehyde and DA, could be responsible for the reinforcing properties of alcohol and for its addictive potential [34, 35]
