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Injections of Dexpanthenol (the form used exclusively intravenously) at 500 mg intramuscularly daily for 5 days decreases the time to a bowel movement in patients with chronic or occasional constipation

Simultaneously, IR depletes GSH, the essential cofactor for GPX4, further compromising its ferroptosis-suppressing function ( The relative contributions of iron dysregulation, ROS production, transcriptional regulation, and antioxidant defense impairment to ferroptosis in irradiated lens cells may depend on factors such as radiation type, dose, and duration of exposure

Look for supplements that have been third-party tested for purity and potency, and consider consulting with a healthcare provider before beginning any new supplementation regimen

This mechanism mitigates lipid peroxidation and suppresses ferroptosis via the Fenton reaction (Zhao et al., 2025)