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A recently published patent WO2020193838 consists of a pharmaceutical composition for intranasal treatment of depression using nanoparticles of a serotonin-norepinephrine reuptake inhibitor drug encapsulated in PLGA polymer and stabilized with cryoprotectants like trehalose

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As a major part of the ANS, the vagus nerve influences functions such as heartrate, breathing, and digestion (Figure 7)