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The etiopathogenesis of FM is thought to involve complex interactions between genetic predisposition and environmental and biological factors, with central sensitization playing an important role [1, 5]

Significant technological advances in gene manipulation methods, DBS devices and software, and neuroimaging, in combination with increased awareness of the methodological issues that have so far hampered PD therapeutic research have led to novel pharmacotherapeutic and non-pharmacological strategies that are under ongoing assessment

Target seven to nine hours of quality sleep nightly

doi: 10.1016/j.toxrep.2015.01.002