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While muscle tissue adapts quickly to increased load, connective tissue does not

In oocytes from aged mice, enhancing Parkin-mediated mitophagy by supplementing spermidine improved oocyte fertility

In contrast to most terminally differentiated somatic cells, adult stem cells undergo extensive proliferation and differentiation processes, increasing the likelihood of DNA damage during DNA replication

Mol Cell Biol 28(10):32813289
