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CircRNAs found in circulating exosomes in the blood are a new and trustworthy class of biomarkers in patients with colorectal cancer (CRC) [512]

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Basic Neurochemistry NCBI Bookshelf

However, instead of enhancing tumor antigen transportation and immune cell trafficking to the TDLNs, tumor-associated lymphatic endothelium can impede anti-cancer T-cell response and promote cancer cell immune evasion and metastasis (9397) ( Figure 1 )
