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On the other hand, metabolic stress activates the JNK signaling pathway, which can inhibit the tyrosine phosphorylation level of IRS in target tissue cell membranes, which in turn affects downstream insulin-related signaling such as PI3K and Akt/PKB, resulting in IR (99, 159)

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HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis

The role of IL-6 in cachexia-related sarcopenia has been previously discussed in this section and elevated levels of TNF-, IL-6 as well C-reactive protein (CRP) have been detected in sarcopenic people, further suggesting a link between systemic inflammation and muscle degeneration [162, 163]