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The exact dose may change based on individual needs and the severity of the deficiency

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[3] [6] Alternatively, it has been suggested that oral parafunctional activities such as lip or cheek chewing become more pronounced during periods of stress

Also, physiological processes related to the aging of the organism [44], pharmacotherapy with certain drugs (such as metformin, proton pump inhibitors of gastric parietal cells (including omeprazole, pantoprazole), and histamine H2 receptor antagonists, e.g., ranitidine), or resection of parts of the gastrointestinal tract (stomach, small intestine) [4,24] may result in absorption disorders of this vitamin of varying intensity