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493 During the treatment of patients with moderate to severe UC, persistent intestinal emergencies improve and are relieved, rectal bleeding is significantly reduced, 494,495,496 and C-reactive protein and fecal calprotectin levels decrease to varying degrees

The liver injury criteria were vacuolisation of hepatocytes and pyknotic hepatocyte nuclei, activation of Kupffer cells, and enlargement of sinusoids

Anecdotal reports significantly outpace controlled trial evidence
