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[DOI] [PMC free article] [PubMed] [Google Scholar] Laugesen S, Enggaard TP, Pedersen RS, Sindrup SH, and Brosen K (2005) Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol
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From that point, the frequency drops to every other day for seven doses
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