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Description
It is mainly produced by the liver (accounting for 75 % of circulating IGF-1) secondary to growth hormone (GH) and insulin endocrine stimulation in the liver

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In a healthy context, that's fantasticit helps heal wounds and regenerate tissue

This and many other hitherto uncharacterised factors induce accumulation of pathogenic inclusions differently termed as Lewy bodies in neurons of PD patients (Marotta et al., 2021) or glial cytoplasmic inclusions in oligodendrocytes of Multiple System Atrophy (MSA) patients (Reddy and Dieriks, 2022)
