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See our [NAD+ dosing guide](/guides/nad-plus-dosing-guide-how-much-to-take) for protocols, or [explore NAD+ products](/products/nad-001)

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69 - 73 Likewise, it occurs after vascular occlusion, 94 neuromuscular blockade (succinylcholine application), 45 potassium or magnesium overload, 43 , 111 dopamine system failure (nigrostriatal damage [1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP]), 130 vesicle depletion (reserpine), 132 dopamine receptors blockade (haloperidol and other dopamine antagonists), 47 , 116 , 135 or dopamine receptors supersensitivity (amphetamine after haloperidol) 133 or dopamine over-release (amphetamine)