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Why the Uric Acid Test is Done: This test helps evaluate: Gout (a type of arthritis caused by uric acid crystal buildup) Kidney function and risk of kidney stones Metabolic disorders Chemotherapy or radiation patients (to monitor tumor lysis syndrome) Normal Range: Men: 3.4 7.0 mg/dL Women: 2.4 6.0 mg/dL (Ranges may vary by laboratory.) High Uric Acid (Hyperuricemia): Gout (painful joint inflammation, especially in the big toe) Chronic kidney disease Dehydration or metabolic syndrome High purine diet or certain medications Low Uric Acid (Hypouricemia): Liver disease Certain genetic or metabolic conditions Medications that increase uric acid excretion Clinical Insight: While elevated uric acid is commonly associated with gout, its also a risk marker for cardiovascular diseases, hypertension, and renal dysfunction

216 IsraelsonA.ArbelN.Da CruzS.IlievaH.YamanakaK.Shoshan-BarmatzV.et al (2010)

Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage

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