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Biomed Pharmacother 106:12921299 urkovi-Perica M, Hrenovi J, Kugler N et al (2015) Antibacterial activity of Pinus pinaster bark extract and its components against multidrug-resistant clinical isolates of Acinetobacter baumannii

In the context of AD, fisetin has been shown to modulate inflammatory pathways and maintain cognitive function in AD transgenic mice (53) and to enhance memory and induce hippocampal long-term potentiation in rats (54)

Endocrinology (2005) 146:417988

Alkyl interaction with Phe113 further stabilizes the ligand through hydrophobic forces and interaction with Arg114 maintains ligand orientation (Figure 9)