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Pooled effect sizes showed no difference between all routes of administration to increase Hb without substantial statistical evidence (Fig

Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed

Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation