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[20] It is important to note that doses higher than 600 mg/day intravenously have not been shown to confer additional clinical benefit, but they may increase side effects
This makes it a preferred option for those who need quick and effective relief
To ascertain a comprehensive role of the UPR in cystine uptake inhibition-induced ferroptosis, we examined the status of the three canonical UPR pathways: (1) IRE1-XBP1s, (2) PERK-ATF4-eIF2 and (3) ATF6 in both MDA-MB-231 and Panc-1 cells upon erastin treatment or cystine starvation
10.1212/wnl.48.6.1583 132 LiuM.ChoiD
