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Moreover, high glucose-induced cell dysfunction, such as impaired osteogenic differentiation potential, has been considered as one of the most significant challenges in stem cell-based (especially PDLSC-based) periodontal therapies for diabetic patients (4244)
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The action of this oxoferryl porphyrin radical on tyrosine 385 creates a tyrosyl radical that abstracts a bis -allylic hydrogen and forms a conjugated radical