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Description
The goal is to normalize hormone levels rather than simply replacing them
4-Hydroxythalidomide based PROTACs By exploiting the reactivity of the phenolic group of 4-hydroxythalidomide, its direct alkylation allows the synthesis of diverse and versatile starting building blocks for subsequent incorporation into the construction of cereblon-based PROTACs, e.g., via amidation, alkylation or click-chemistry reactions 97,110,111,112
Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice
doi: 10.1002/art.27318 149 ManoussakisMNKapsogeorgouEK
