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As the combined stimuli of exercise and cold may increase the risk for adverse cardiovascular events in susceptible individuals by elevating myocardial work ( Reference Manou-Stathopoulou, Goodwin and Patterson 14 ) , therapies targeted to attenuate cardiac afterload during stress would be cardioprotective

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10.2147/HP.S202775 131 SongQ.ChenY.WangJ.HaoL.HuangC.GriffithsA.et al (2020)

To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed
