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Astragaloside IV, a cycloartane-type triterpene glycoside derived from Astragalus mongholicus Bunge [Fabaceae], has shown protective effects against this dysfunction by promoting vasodilation via the PI3K/Akt/eNOS signaling pathway

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Finally, we critically evaluate emerging rejuvenation strategies, translational approaches for next-generation therapies, persistent challenges and promising directions for future research