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The researchers on this paper speculated that thymoquinone, or TQ, the primary active constituent of [BSO], may have been primarily responsible for the effect because TQ protects cells against oxidative damage induced by a variety of free radical-generating pathologies, and it also stimulates the production of acetylcholine, which causes the release of melanin and darkening of the skin through stimulation of cholinergic receptors

Fountoulakis et al., 2025) as well as antioxidant therapeutic approaches (Mynarska et al., 2024

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Diabetes mellitus Numerous experimental studies and surveys have indicated that patients with hyperglycemia are more prone towards the risk of coronary complications