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discovered, through experimental studies, that the expression of NADPH oxidase 4 (Nox4) was upregulated while the expression of Nrf2/HO-1 was downregulated in the hippocampus of diabetic rats (48)

In conclusion, the results of the present study suggest that the ability of ibuprofen, prednisone and betamethasone to protect against OA results from inhibition of IL-6 and IL-8 expression, subsequent suppression of NF-B and STAT3 signaling pathways, and, ultimately, reduction of collagen I, MMP-1 and MMP-13 expression

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