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Interestingly, the transient elevation of inflammation seen on day 14 in the amlodipine group may reflect a beneficial early immune response, characterized by the recruitment of M1 macrophages, which later polarize into an M2 phenotype

While the peptide may help normalize immune function, its effects on established autoimmune diseases remain insufficiently characterized

Additionally, improved organization of the ECM was observed with increased loading as seen by H&E staining, a distinction that became particularly evident at 3-weeks post-injury

Continued interdisciplinary collaborations and global investment will be critical to fully realize the therapeutic potential of antibodies in the coming decades