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Metabolism: Individual differences in liver enzymes, particularly the cytochrome P450 family, can significantly alter how quickly a compound is broken down and cleared

The research basethough extensive, comprising over 100 published studiesis entirely preclinical (animal models and in vitro experiments)

VinuNavarroJHerrero-CerveraAGarca-CubasMAndrs-BlascoIMartnez-HervsSet alThe GLP-1 analogue lixisenatide decreases atherosclerosis in insulin-resistant mice by modulating macrophage phenotype

Chemical reaction in which reactants combine to form a new compound, with one reactant giving up an atom of hydrogen and another reactant giving up a hydroxyl group (OH)