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Furthermore, a notable rise in the expression levels of genes associated with autophagy, as well as a higher quantity of autophagic vacuoles and lysosomes, has been detected in degenerated intervertebral discs and the annulus fibrosus (181, 182)

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Then, we investigated whether DRD2 activation upregulates Nrf2 targets in primary astrocytes

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Under normal, resting conditions reactive oxygen species are removed from the cell preventing any subsequent damage

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